Candesartan can help in treating brain injury

Outcome

Primary Outcome: Candesartan can help in treating brain injury as it canprompt a sustained proangiogenic response in the brain after ischemic stroke. The drug limits the cerebral inflammation and lesion volume, and protect cerebral blood flow (Timaru-Kast, et al., 2019),help functional outcome that is influenced by integrating new cells in a neuronal circuit and controlled cortical impact induced cognitive impairment as we know that reduce the level of neurogenesis might be inadequate in preventing interference between the old and new memory, thus separating pattern and clearing old associations and taking candesartan which induced a sustained proangiogenic response help in treating better cognitive outcome.

Measure:  Global functional outcome measure will help in measuring functional outcome and Cognitive measurement can be done using the Postgraduate Institute Memory Scale or Montreal Cognitive Assessment (MoCA). Neuroprotective measures are established on theadministration of cerebral perfusion pressure and intracranial pressure to improve the oxygenation and cerebral blood (Stenberg et al., 2020).

Secondary outcome: we need to measure BP usinga sphygmomanometer,as candesartan keeps blood vessels from narrowing that helps in improving blood flow lowering blood pressure. Candesartan lowers the pulse pressure (P < 0>

Reference:

Raghuraman, R., Carney, C., Mullahy, H., Ogunseitan, O., Wang, D. and Antonios, T.F.T., 2017. Effects of candesartan versus amlodipine on capillary rarefaction, pulse wave velocity, and central blood pressure in patients with essential hypertension. Journal of Non Invasive Vascular Investigation, 2, p.008.

Timaru-Kast, R., Gotthardt, P., Luh, C., Huang, C., Hummel, R., Schaefer, M.K. and Thal, S.C., 2019. Angiotensin II receptor 1 blockage limits brain damage and improves functional outcome after brain injury in aged animals despite age-dependent reduction in AT1 expression. Frontiers in aging neuroscience, 11.

Stenberg, J., Håberg, A.K., Follestad, T., Olsen, A., Iverson, G.L., Terry, D.P., Karlsen, R.H., Saksvik, S.B., Karaliute, M., Ek, J.A. and Skandsen, T., 2020. Cognitive reserve moderates cognitive outcome after mild traumatic brain injury. Archives of physical medicine and rehabilitation, 101(1), pp.72-80.

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